Cis-4,5-didehydro-9-deoxy-PGF compounds

ABSTRACT

Prostaglandin analogs with the following cyclopentane ring structure: ##STR1## are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for some of the same pharmacological purposes as the prostaglandins.

The present application is a continuation application of Ser. No.786,715, filed Apr. 11, 1977 now abandoned; which is a division of Ser.No. 614,243, filed Sept. 17, 1975, now U.S. Pat. No. 4,033,989.

The present invention relates to prostaglandin analogs, for which theessential material constituting disclosure therefor is incorporated byreference here from Ser. No. 614,243, now U.S. Pat. No. 4,033,989.

I claim:
 1. A prostaglandin analog of the formula ##STR2## wherein M ISONE TO 5, INCLUSIVE:Wherein M₁ is ##STR3## wherein R₅ and R₆ arehydrogen or methyl, with the proviso that one of R₅ and R₆ is methylonly when the other is hydrogen; Wherein L₁ is ##STR4## or a mixture ofand ##STR5## wherein R₃ and R₄ are hydrogen, methyl, or fluoro, beingthe same or different, with the proviso that one of R₃ and R₄ is fluoroonly when the other is hydrogen or fluoro; Wherein R₁ is hydrogen, alkylof one to 12 carbon atoms, inclusive. cycloalkyl of 3 to 10 carbonatoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl,phenyl substituted with one, two, or three chloro or alkyl of one to 3carbon atoms, inclusive or a pharmacologically acceptable cation; andWherein g is one, 2, or
 3. 2. A compound according to claim 1, wherein mis
 3. 3. A compound according to claim 2, wherein g is
 3. 4.2A,2B-Dihomo-cis-4,5-didehydro-15-epi-cis-13-9-deoxy-PGF₁, a compoundaccording to claim
 3. 5. A compound according to claim 4, wherein g isone.
 6. CIS-4,5-Didehydro-15-epi-cis-13-9-deoxy-PGF₁, a compoundaccording to claim
 5. 7. CIS-4,5-Didehydro-15-epi-cis-13-9-deoxy-PGF₁,methyl ester, a compound according to claim 5.